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KMID : 0365819690090020171
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Journal of Pusan Medical College
1969 Volume.9 No. 2 p.171 ~ p.180
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Effects of Adrenergic Blocking Agents, on the Phosphorylase Activity of the Removed Human Uterus
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Abstract
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The author studied the effects of adrenergic agents and adrenergic blocking agents on the phosphroylase activity of the removed human uterus, especially, the relative ability of several adrenergic blocking art^nts to prevent adrenergic-induced increases in the uterine phosphorylase activity investigated.
The results were as follows;
1. Epinephrine, norepinephrine, isoproterenol and quinterenol activated th:: phosphorylase activity of the removed human uterus in the following order;
Epinephrine> norepinephrine> isoproterenol> quinterenol.
2. The phosphorylase activity of the removed human uterus slightly activated by adrenergic a-blocking agents such as phenoxybenzamine, ergotamine and phentolarnine, but slightly inhibited by adrenergic [3-blocking agents such as pronethalol and propranolol.
3. The uterine phosphorylase activation by epinephrine usually not blocked by either kind of blocking agents alone, but blocked completely by a combination of two.
4. The uterine phosphorylase activation by norepinephrine not blocked by adrenergic fr- blocking agents such as pronethalol and propranolol, but blocked by adrenergic a- blocking agents such as phenoxybenzamine, ergotamine and phentolamine.
5. The uterine phosphorylase activation by isoproterenol and quinterenol blocked by adrenergic 13-blocking agents such as pronethalol and propranolol, but not blocked by adrenergic a-blocking agents such as phenoxybenzamine, ergotamine and phentolamine.
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